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Proceedings of the National Academy of Sciences current issue
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Proceedings of the National Academy of Sciences RSS feed -- current issue
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[Letters] NMR data do not implicate a phosphorane in the T4 DNA ligase reaction
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[Letters] Reply to Hengge: On the 31P chemical shifts of the phosphorane compounds
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[Letters] Appetitive and addictive factors pertinent to analysis of neuroscience studies of sexuality
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[Letters] Differential course of HIV-1 infection and APOE polymorphism
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[This Week in PNAS] In This Issue
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[Commentary] On the way to mass-scale production of perfect bulk diamonds
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[Commentary] Rolling out DNA nanostructures in vivo
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[Commentary] Big discovery for biogenic magnetite
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[Profile] Profile of Francisco Bezanilla
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[Biophysics] Inaugural Article: S4-based voltage sensors have three major conformations
Voltage sensors containing the charged S4 membrane segment display a gating charge vs. voltage (Q–V) curve that depends on the...
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[Medical_Sciences] Revealing the spatial distribution of a disease while preserving privacy
Datasets describing the health status of individuals are important for medical research but must be used cautiously to protect patient...
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[Applied_Mathematics] Stochastic models for convective momentum transport
The improved parameterization of unresolved features of tropical convection is a central challenge in current computer models for long-range ensemble...
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[Applied_Physical_Sciences] From the Cover: Enhanced optical properties of chemical vapor deposited single crystal diamond by low-pressure/high-temperature annealing
Single crystal diamond produced by chemical vapor deposition (CVD) at very high growth rates (up to 150 µm/h) has been...
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[Biochemistry] In vivo cloning of artificial DNA nanostructures
Mimicking nature is both a key goal and a difficult challenge for the scientific enterprise. DNA, well known as the...
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[Chemistry] Mediator-assisted water oxidation by the ruthenium "blue dimer" cis,cis-[(bpy)2(H2O)RuORu(OH2)(bpy)2]4+
Light-driven water oxidation occurs in oxygenic photosynthesis in photosystem II and provides redox equivalents directed to photosystem I, in which...
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[Chemistry] Interactions between amino acid side chains in cylindrical hydrophobic nanopores with applications to peptide stability
Confinement effects on protein stability are relevant in a number of biological applications ranging from encapsulation in the cylindrical cavity...
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[Chemistry] An artificial molecular switch that mimics the visual pigment and completes its photocycle in picoseconds
Single molecules that act as light-energy transducers (e.g., converting the energy of a photon into atomic-level mechanical motion) are examples...
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[Geology] From the Cover: Gigantism in unique biogenic magnetite at the Paleocene-Eocene Thermal Maximum
We report the discovery of exceptionally large biogenic magnetite crystals in clay-rich sediments spanning the Paleocene–Eocene Thermal Maximum (PETM) in...
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[Geophysics] Toward understanding early Earth evolution: Prescription for approach from terrestrial noble gas and light element records in lunar soils
Because of the almost total lack of geological record on the Earth's surface before 4 billion years ago, the history...
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[Evolution] The goat domestication process inferred from large-scale mitochondrial DNA analysis of wild and domestic individuals
The emergence of farming during the Neolithic transition, including the domestication of livestock, was a critical point in the evolution...
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[Anthropology] A 12,000-year-old Shaman burial from the southern Levant (Israel)
The Natufians of the southern Levant (15,000–11,500 cal BP) underwent pronounced socioeconomic changes associated with the onset of sedentism and...
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[Applied_Biological_Sciences] High-throughput sequencing allows the identification of binding molecules isolated from DNA-encoded chemical libraries
DNA encoding facilitates the construction and screening of large chemical libraries. Here, we describe general strategies for the stepwise coupling...
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[Applied_Biological_Sciences] From the Cover: Environmental signatures associated with cholera epidemics
The causative agent of cholera, Vibrio cholerae, has been shown to be autochthonous to riverine, estuarine, and coastal waters along...
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[Applied_Biological_Sciences] Genome-wide screen of Saccharomyces cerevisiae null allele strains identifies genes involved in selenomethionine resistance
Selenomethionine (SeMet) is a potentially toxic amino acid, and yet it is a valuable tool in the preparation of labeled...
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[Applied_Biological_Sciences] Protein evolution with an expanded genetic code
We have devised a phage display system in which an expanded genetic code is available for directed evolution. This system...
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